Regulation of proplatelet formation and platelet release by integrin αIIbβ3
نویسندگان
چکیده
word count: 196 Text word count: 3665 Heading: Hematopoiesis Blood First Edition Paper, prepublished online May 2, 2006; DOI 10.1182/blood-2005-11-011957 Copyright © 2006 American Society of Hematology For personal use only. on August 31, 2017. by guest www.bloodjournal.org From
منابع مشابه
Mitochondrially mediated integrin αIIbβ3 protein inactivation limits thrombus growth.
When platelets are strongly stimulated, a procoagulant platelet subpopulation is formed that is characterized by phosphatidylserine (PS) exposure and epitope modulation of integrin αIIbβ3 or a loss of binding of activation-dependent antibodies. Mitochondrial permeability transition pore (mPTP) formation, which is essential for the formation of procoagulant platelets, is impaired in the absence ...
متن کاملOutside-In Signalling Generated by a Constitutively Activated Integrin αIIbβ3 Impairs Proplatelet Formation in Human Megakaryocytes
BACKGROUND The interaction of megakaryocytes with matrix proteins of the osteoblastic and vascular niche is essential for megakaryocyte maturation and proplatelet formation. Fibrinogen is present in the vascular niche and the fibrinogen receptor α(IIb)β(3) is abundantly expressed on megakaryocytes, however the role of the interaction between fibrinogen and α(IIb)β(3) in proplatelet formation in...
متن کاملDirect interaction of kindlin-3 with integrin αIIbβ3 in platelets is required for supporting arterial thrombosis in mice.
OBJECTIVE Kindlin-3 is a critical supporter of integrin function in platelets. Lack of expression of kindlin-3 protein in patients impairs integrin αIIbβ3-mediated platelet aggregation. Although kindlin-3 has been categorized as an integrin-binding partner, the functional significance of the direct interaction of kindlin-3 with integrin αIIbβ3 in platelets has not been established. Here, we eva...
متن کاملBidirectional integrin αIIbβ3 signalling regulating platelet adhesion under flow: contribution of protein kinase C
Platelet adhesion on von Willebrand factor (vWf) requires the co-ordinated adhesive function of glycoprotein Ib/V/IX and integrin αIIbβ3. Recent evidence [Nesbitt, Kulkarni, Giuliano, Gonclaves, Dopheide, Yap, Harper, Salem and Jackson (2002) J. Biol. Chem. 277, 2965–2972] suggests that outside-in signals from both receptors play important roles in regulating plateletadhesion dynamics under flo...
متن کاملPaxillin is an intrinsic negative regulator of platelet activation in mice
BACKGROUND Paxillin is a LIM domain protein localized at integrin-mediated focal adhesions. Although paxillin is thought to modulate the functions of integrins, little is known about the contribution of paxillin to signaling pathways in platelets. Here, we studied the role of paxillin in platelet activation in vitro and in vivo. METHODS AND RESULTS We generated paxillin knockdown (Pxn-KD) pla...
متن کامل